In the movie The Company You Keep, the main character (played by Shia LeBeouf) wears a pair of Persol 3007 eyeglasses.

In the movie Mission: Impossible – Ghost Protocol, Tom Cruise sports a pair of Persol PO2978S sunglasses

After he left the popular television series Two and a Half Men, Charlie Sheen has been spotted regularly in public wearing Persol eyewear.

Stephen Dorff, as Johnny Marco, a Hollywood bad-boy, wears black Persol PO2932S sunglasses in Somewhere.

In the movie The American, George Clooney wears a pair of havana colored Persol 2883 sunglasses.

David Duchovny wears Persol 2867 sunglasses in the movie The Joneses.

Harvey Keitel wears a pair of Persol 2857 eyeglasses when arriving at the premiere of "Precious: Based on the Novel Push by Sapphire".

Tom Cruise has been spotted wearing the new Persol 2931 sunglasses (havana frame, brown lenses) while filming the movie Knight and Day.

In Henry Poole is Here, Luke Wilson wears a pair of Persol 2813, with a Black frame and Gray Green lenses.

In the 2006 James Bond movie Casino Royale, Giancarlo Giannini wears a pair of Persol sunglasses.